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Random, Placebo-Contr Study of Tolcapone in Pts with Fluctuating Parkinson Dis Trtd With Levodopa-Carbidopa Arch Neurol 55:1089-1095, Adler,C.H.,et al, 1998 See this aricle in Pubmed Article Abstract Tolcapone was well tolerated and substantially increased on time and reduced off time in patients with fluctuating Parkinson disease. Additionally,levodopa requirements were significantly decreased.

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(click to filter results - removes previous filter) catechol-o-methyltransferase inhibitor L-dopa Parkinson disease Parkinson disease,fluctuations in Parkinson disease,on-off phenomena in Parkinson disease,treatment of sinemet tolcapone treatment of neurologic disorder

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